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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13364 | YAP/TAZ inhibitor-1 | ROCK | |
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay). | |||
T60218 | YAP/TAZ inhibitor-2 | YAP | |
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1]. | |||
T60148 | MSC-4106 | YAP | |
MSC-4106, an orally active and potent YAP/TAZ-TEAD inhibitor, disrupts TEAD1 and TEAD3 auto-palmitoylation and demonstrates significant efficacy in the NCI-H226 tumor xenograft model [1]. | |||
T60013 | GA-017 | Others | |
GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell prolifer... | |||
T81056 | SWTX-143 | YAP | |
SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating anti... | |||
T78558 | GNE-7883 | ||